Search Results - (Author, Cooperation:C. Marone)
-
1Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2013-08-21Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
2Latest Papers from Table of Contents or Articles in PressB. Bolukbasi ; N. Berente ; J. Cutcher-Gershenfeld ; L. Dechurch ; C. Flint ; M. Haberman ; J. L. King ; E. Knight ; B. Lawrence ; E. Masella ; C. McElroy ; B. Mittleman ; M. Nolan ; M. Radik ; N. Shin ; C. A. Thompson ; S. Winter ; I. Zaslavsky ; M. L. Allison ; D. Arctur ; J. Arrigo ; A. K. Aufdenkampe ; J. Bass ; J. Crowell ; M. Daniels ; S. Diggs ; C. Duffy ; Y. Gil ; B. Gomez ; S. Graves ; R. Hazen ; L. Hsu ; D. Kinkade ; K. Lehnert ; C. Marone ; D. Middleton ; A. Noren ; G. Pearthree ; M. Ramamurthy ; E. Robinson ; G. Percivall ; S. Richard ; C. Suarez ; D. Walker
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-11-30Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: *Access to Information ; Periodicals as Topic/*economics ; Research/*economicsPublished by: -
3Articles: DFG German National LicensesBERETTA-PICCOLI, C. ; MARONE, C. ; STÄDLER, P. ; ZIEGLER, W. H. ; RIESEN, W. ; PUSTERLA, C.
Oxford, UK : Blackwell Publishing Ltd
Published 1988Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0021-9673Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0039-9140Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1420-9136Keywords: Key Words: Friction, shear heating, fault strength, shear localization, fault gouge.Source: Springer Online Journal Archives 1860-2000Topics: GeosciencesPhysicsNotes: Abstract —Heat-flow measurements imply that the San Andreas Fault operates at lower shear stresses than generally predicted from laboratory friction data. This suggests that a dramatic weakening effect or reduced heat production occur during dynamic slip. Numerical studies intimate that grain rolling or localization may cause weakening or reduced heating, however laboratory evidence for these effects are sparse. We directly measure frictional resistance (μ), shear heating and microstructural evolution with accumulated strain in layers of quartz powder sheared at a range of effective stresses (σ n = 5 - 70 MPa) and sliding velocities (V = 0.01 - 10 mm/s). Tests conducted at σ n ≥ 25 MPa show strong evidence for shear localization due to intense grain fracture. In contrast, tests conducted at low effective stress (σ n = 5 MPa) show no preferential fabric development and minimal grain fracture hence we conclude that non-destructive processes such as grain rolling/sliding, distributed throughout the layer, dominate deformation. Temperature measured close to the fault increases systematically with σ n and V, consistent with a one-dimensional heat-flow solution for frictional heating in a finite width layer. Mechanical results indicate stable sliding $(\mu \sim 0.6)$ for all tests, irrespective of deformation regime, and show no evidence for reduced frictional resistance at rapid slip or high effective stresses. Our measurements verify that the heat production equation $(q =\mu \sigma_n V)$ holds regardless of localization state or fracture regime. Thus, for quasistatic velocities (V≤ 10 mm/s) and effective stresses relevant to earthquake rupture, neither grain rolling/sliding or shear localization appear to be a viable mechanism for the dramatic weakening or reduced heating required to explain the heat flow paradox.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesVidale, J. E. ; ElIsworth, W. L. ; Cole, A. ; Marone, C.
[s.l.] : Nature Publishing Group
Published 1994Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] We analyse 18 nearly identical earthquakes that occurred between July 1980 and September 1991 (Table 1). The events were about magnitude 1.5, and were on the Calaveras fault near the southern end of the magnitude-6 1984 Morgan Hill earthquake aftershock zone12. They had identical right-lateral ...Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1432-1041Keywords: Isradipine ; Haemodialysis ; pharmacokinetics ; dialysabilitySource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMedicineNotes: Summary The pharmacokinetics of isradipine, a calcium-channel blocker, have been studied in eight patients on chronic haemodialysis. A single oral dose of 5 mg was administered on both a non-haemodialysis and a haemodialysis day and the plasma concentrations of isradipine were analyzed. The mean cmax, tmax, AUC, and t1/2 in plasma on the non-haemodialysis day were 5.2 ng·ml−1, 1.4 h, 23.8 ng·h·ml−1, and 3.1 h, respectively. The dialysis clearance of isradipine was negligible (5.0 ml·min−1). The t1/2 values during haemodialysis were not significantly different from those observed during the same period post dose on the non-haemodialysis day. The study demonstrates that supplemental doses of isradipine are not necessary in these patients since isradipine is not significantly removed by haemodialysis.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesClearance of ceftriaxone during haemodialysis using cuprophane, haemophane and polysulfone dialysersStaff View
ISSN: 1432-1041Keywords: Key wordsCeftriaxone ; HaemodialysisSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMedicineNotes: Abstract Objective: The purpose of the present study was to investigate whether the clearance of ceftriaxone during haemodialysis is influenced by the type of membrane used (cuprophane, haemophane or polysulphone). Methods: After administration of a single 2-g dose of ceftriaxone, the half-life of the drug during haemodialysis and the clearance of the dialyser were measured. Results: The mean dialysis clearance normalised for square metre of membrane surface was significantly different for the three dialysers (haemophane 24 ml · min−1 · m−2; cuprophane 32 ml · min−1 · m−2; polysul phone 42 ml · min−1· m−2). Conclusions: Polysulphone membranes are more permeable and increase the extraction of ceftriaxone more than the other dialysers studied (haemophane and cuprophane membranes). These results, taken together with previous data, show that an increase of the dose in dialysis patients treated with large surface (〉0.8 m2) and high permeability membranes might be necessary.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1432-1041Keywords: piretanide ; furosemide ; nephrotic syndrome ; loop diuretic ; natriuresis ; free water clearanceSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMedicineNotes: Summary The mode and site of action of the new diuretic agent piretanide were investigated in man. The effect of a single oral dose of 12 mg was compared with that of furosemide 80 mg p.o. in 6 patients with the nephrotic syndrome. Piretanide showed a greater diuretic and natriuretic response than furosemide during maximal water diuresis, but the effect was similar in the hydropenic state. Like furosemide, piretanide decreased free water clearance relative to delivery during water diuresis and the reabsorption of solute-free water during hydropenia. This inhibitory action on both the concentrating and diluting urinary mechanisms demonstrates an effect of piretanide localized in the ascending limb of Henle's loop. Consistent alterations in glomerular filtration rate, renal blood flow or filtration fraction were not observed.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1432-1041Keywords: piretanide ; furosemide ; renal insufficiency ; loop diuretic ; natriuresis ; pharmacokinetics ; diuretic effect ; kaliuresisSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMedicineNotes: Summary The natriuretic effect of the new loop diuretic piretanide was investigated in patients with severe renal insufficiency and was compared with that of furosemide. In the first study 4 hospitalized patients (serum creatinine 407 to 1220 µmol/l) were examined after administration of piretanide (12, 24, 48 and 96 mg to two patients, and 24, 48, 96 and 192 mg to 2 other subjects, given every third day). In the second study 6 hospitalized patients (serum creatinine 194 to 698 µmol/l) were studied after receiving orally 2 different doses of piretanide and 2 different doses of furosemide orally, given every fourth day. The mean natriuretic effect of 48 mg and 96 mg piretanide was 250 and 340% of the control value for the entire group, and 311 to 480% in the subgroup of patients with serum creatinine below 530 µmol/l. For a given dose the natriuresis was inversely correlated with renal function, and at a given serum creatinine level the natriuretic response was dose-dependent. The drug had less effect on water and potassium diuresis than on natriuresis. No significant difference in natriuretic effect was found on comparison with furosemide given in the ratio furosemide: piretanide 3.33:1. The pharmacokinetic data showed a direct correlation between the dose and the mean plasma concentration and also between urinary recovery of the drug and the measured natriuretic response.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1432-1041Keywords: piretanide ; renal insufficiency ; furosemide ; pharmacokinetics ; loop diureticSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMedicineNotes: Summary The pharmacokinetics of piretanide was studied in 10 patients with chronic renal failure. After administration of a high oral dose (12 to 192 mg) of piretanide the kinetics behaved according to an open 2-compartment model. The elimination constant in the first phase (α) ranged from 0.385 to 0.756 h−1 and in the second phase (β) from 0.079 to 0.274 h−1. The corresponding elimination half-lives ranged from 55 to 108 min (t1/2 α) and from 152 to 524 min (t1/2 β). Only an average of 2.8% of the orally administered drug was recovered in 24 h urines. Nevertheless, a good correlation was found between urinary recovery or renal clearance of the drug and residual renal function. The elimination of piretanide by non-renal mechanisms appeared to be increased when renal function was greatly diminished.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1432-1440Keywords: Serum proteins ; renal transplantation ; prelbumin ; immunoglobulins ; acute phase reaction ; Serumeiweiße ; Nierentransplantation ; Präalbumin ; Immunoglobuline ; AkutphasenproteineSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Zusammenfassung Bei 20 nierentransplantierten Patienten mit stabiler Nierenfunktion wurden 16 Serumproteine systematisch untersucht. Dabei wurden folgende stark von der Norm abweichenden Befunde erhoben: eine konstante Erhöhung des Praealbumins und des sauren α1-Glykoproteins, des Haptoglobins, des Hämopexins und des β2-Glykoproteins sowie eine relativ häufige Erhöhung des α2-Makroglobulins. Es konnten keine Beziehungen zwischen den Serumeiweißveränderungen einerseits und den Grund- oder den Begleitkrankheiten, der Therapie oder der Dauer der Transplantation andererseits eruiert werden.Notes: Summary We have investigated 16 serum proteins in 20 patients with stable renal function after renal transplantation. Our investigations have shown the following substantial findings: a regular increase of prealbumin, α1-glycoprotein, haptoglobin, hemopexin and β2-glycoprotein, as well as a rather frequent increase of α2-macroglobulin. As far as variations of the serum protein levels are concerned there was no correlation with kidney disease, accompanying illnesses, therapy or interval since transplantation.Type of Medium: Electronic ResourceURL: