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1Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-04-10Publisher: BMJ PublishingElectronic ISSN: 2044-6055Topics: MedicineKeywords: Open access, Cardiovascular medicinePublished by: -
2Latest Papers from Table of Contents or Articles in PressC. C. Smith ; Q. Wang ; C. S. Chin ; S. Salerno ; L. E. Damon ; M. J. Levis ; A. E. Perl ; K. J. Travers ; S. Wang ; J. P. Hunt ; P. P. Zarrinkar ; E. E. Schadt ; A. Kasarskis ; J. Kuriyan ; N. P. Shah
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-04-17Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Benzothiazoles/pharmacology/*therapeutic use ; Cell Line, Tumor ; DNA Mutational Analysis ; Drug Resistance, Neoplasm/genetics ; Humans ; Leukemia, Myeloid, Acute/*drug therapy/*genetics/metabolism ; Models, Molecular ; Molecular Structure ; *Molecular Targeted Therapy ; Mutation/*genetics ; Phenylurea Compounds/pharmacology/*therapeutic use ; Protein Binding ; Protein Structure, Tertiary/genetics ; Recurrence ; Reproducibility of Results ; fms-Like Tyrosine Kinase 3/*antagonists & inhibitors/*genetics/metabolismPublished by: -
3Latest Papers from Table of Contents or Articles in PressM A Trigg, C E Birch, J C Neal, P D Bates, A Smith, C C Sampson, D Yamazaki, Y Hirabayashi, F Pappenberger, E Dutra, P J Ward, H C Winsemius, P Salamon, F Dottori, R Rudari, M S Kappes, A L Simpson, G Hadzilacos and T J Fewtrell
Institute of Physics (IOP)
Published 2018Staff ViewPublication Date: 2018-09-11Publisher: Institute of Physics (IOP)Print ISSN: 1748-9318Electronic ISSN: 1748-9326Topics: BiologyEnergy, Environment Protection, Nuclear Power EngineeringPublished by: -
4Articles: DFG German National LicensesDavidson, S. J. ; Foster, J. M. ; Smith, C. C. ; Warburton, K. A. ; Rose, S. J.
Woodbury, NY : American Institute of Physics (AIP)
Published 1988Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: We report the application of a technique for performing opacity measurements on hot, dense plasmas. Plasmas were generated by using the x rays emitted from a laser-produced gold plasma to heat an aluminum sample. Observations were made using the technique of point projection spectroscopy. The distribution of ion stages observed is compared with predictions based on Saha distributions, at densities and temperatures deduced from hydrodynamic simulations.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesSmith, C. C. T. ; Bradford, H. F. ; Thompson, E. J. ; MacDermot, J.
Oxford, UK : Blackwell Publishing Ltd
Published 1980Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract: The actions of purified β-bungarotoxin (5 or 10 μg/ml) on the metabolic and transmitter-releasing properties of rat cortical synaptosomes was studied. The toxin stimulated control respiratory rates, but prevented the respiratory response to veratrine. Tissue potassium levels were greatly reduced (54%) and endogenous glutamate, aspartate and GABA showed increased levels of release (10- to 25-fold), but other amino acids were unaffected or showed much smaller changes. Tissue levels of these amino acids were reduced in proportion. The toxin inhibited the uptake of [U-14C]GABA (35%) and [U-14C]glutamate (53%) over 5-min incubation periods. This uptake-inhibition was Ca2+-dependent and was reduced by tetrodotoxin. Miniature-end-plate-potential (m.e.p. p.) frequencies at the locust neuromuscular junction (extensor tibialis) were greatly (four- to sevenfold) accelerated by local application of the toxin (5 μg/ml). This effect was reversible and occupied about 20 min. Amplitudes of m.e.p. p.'s were also increased and muscle membrane depolarization occurred. The results are interpreted as being due to a depolarizing action of the toxin.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesSims, N. R. ; Bowen, D. M. ; Allen, S. J. ; Smith, C. C. T. ; Neary, D. ; Thomas, D. J. ; Davison, A. N.
Oxford, UK : Blackwell Publishing Ltd
Published 1983Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract: Indices of presynaptic cholinergic nerve endings were assayed in neocortical biopsy samples from patients with presenile dementia. For those patients in whom Alzheimer's disease was histologically confirmed, [14C]acetylcholine synthesis, choline acetyltransferase activity and choline uptake were all found to be markedly reduced (at least 40%) below mean control values. The changes occurred in samples from both the frontal and temporal lobes and for [14C]acetylcholine synthesis the decrease was similar under conditions of high and low neuronal activity (as assessed by incubations in 31 mM and 5 mM K+ respectively). Samples from other demented patients, in whom the histological features of Alzheimer's disease were not detected, produced values for all three biochemical parameters which were similar to controls. For the total group of patients with presenile dementia there were correlations between values for the three markers of presynaptic cholinergic nerve endings suggestive of a loss of functional activity at these sites in Alzheimer's disease.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesNorris, P. J. ; Smith, C. C. T. ; Belleroche, J. ; Bradford, H. F. ; Mantle, P. G. ; Thomas, A. J. ; Penny, R. H. C.
Oxford, UK : Blackwell Publishing Ltd
Published 1980Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract: The neurochemical effects of the tremorgenic mycotoxins Verruculogen and Penitrem A, which produce a neurotoxic syndrome characterised by sustained tremors, were studied using sheep and rat synaptosomes. The toxins were administered in vivo, either by chronic feeding (sheep) or intraperitoneal injection 45 min prior to killing (rat) and synaptosomes were subsequently prepared from cerebrocortical and spinal cord/medullary regions of rat and corpus striatum of sheep. Penitrem A (400 mg mycelium/kg) increased the spontaneous release of endogenous glutamate, GABA (γ-aminobutyric acid) and aspartate by 213%, 455% and 277%, respectively, from cerebrocortical synaptosomes. Verruculogen (400 mg mycelium/kg) increased the spontaneous release of glutamate and aspartate by 1300% and 1200%, respectively, but not that of GABA from cerebrocortical synaptosomes. The spontaneous release of the transmitter amino acids or other amino acids was not increased by the tremorgens in spinal cord/medullary synaptosomes. Penitrem A pretreatment reduced the veratrine (75 μm) stimulated release of glutamate, aspartate and GABA from cerebrocortical synaptosomes by 33%, 46% and 11%, respectively and the stimulated release of glycine and GABA from spinal cord/ medulla synaptosomes by 67% and 32% respectively. Verruculogen pretreatment did not alter the veratrine-induced release of transmitter amino acids from cerebrocortex and spinal cord/medulla synaptosomes. Penitrem A pretreatment increased the spontaneous release of aspartate, glutamate and GABA by 68%, 62% and 100%, respectively, from sheep corpus striatum synaptosomes but did not alter the synthesis and release of dopamine in this tissue. Verruculogen was shown to cause a substantial increase (300–400%) in the miniature-end-plate potential (m.e.p. p.) frequency at the locust neuromuscular junction. The response was detectable within 1 min, rose to a maximum within 5–7 min and declined to the control rate over a similar period. No change in the amplitude of the m.e.p. p. ‘s was observed. These effects of the tremorgens on transmitter release are interpreted in terms of their mode of action.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesPillay, K ; Solomon, R ; Daubenton, J D ; Sinclair-Smith, C C
Oxford, UK : Blackwell Science Ltd
Published 2004Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Aims: To report a series of four paediatric cases of interdigitating dendritic cell sarcoma (IDCS) and add to the known extranodal sites of occurrence for this tumour. Neoplasms derived from interdigitating dendritic cells are rare, with only 33 cases being reported in the literature (Medline search). These tumours usually occur in lymph nodes in the adult population.Methods and results: The patients were a 10-year-old girl with a large soft tissue mass bulging into the left chest, a 12-year-old girl with a right paraspinal mass, a 21-month-old boy with generalized lymphadenopathy and hepatosplenomegaly and a 6-year-old girl with a large bladder mass. Paraffin blocks and haematoxylin and eosin slides were available in all cases. In addition, immunohistochemistry and electron microscopy were performed. A diagnosis of IDCS was made in all cases.Conclusion: The diagnosis of IDCS can rarely be entertained on clinical information alone. Microscopically, there is a wide spectrum of features. Thus, immunohistochemistry and electron microscopy are crucial in making the diagnosis. The differential diagnosis includes inflammatory pseudotumour, follicular dendritic cell sarcoma, true histiocytic lymphoma, malignant Langerhans cell histiocytosis, anaplastic large-cell lymphoma, melanoma, and a range of sarcomas. IDCS displays aggressive behaviour and approximately half of the patients die of the disease.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0026-7937Topics: Linguistics and Literary StudiesNotes: REVIEWSURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0084-4152Topics: Linguistics and Literary StudiesDescription / Table of Contents: SPANISH STUDIESNotes: ROMANCE LANGUAGESURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0084-4152Topics: Linguistics and Literary StudiesDescription / Table of Contents: SPANISH STUDIESNotes: ROMANCE LANGUAGESURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 0029-2397Topics: English, American StudiesHistoryURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 0029-2397Topics: English, American StudiesHistoryURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0029-2397Topics: English, American StudiesHistoryURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0029-2397Topics: English, American StudiesHistoryURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 0029-2397Topics: English, American StudiesHistoryURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0029-2397Topics: English, American StudiesHistoryURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 0029-2397Topics: English, American StudiesHistoryURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Fig. 1. A, internal flask, round or elongated, with all-glass sea at H; B, outer jacket; C, liquid for distillation; D, higher boiling point; E, water-jacketed condenser; F, thermometer pocket;, ground joints; H, all-glass seal Dimensions of the apparatus are not critical, though the distance ...Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 0007-490XTopics: HistoryRomance StudiesURL: