Search Results - (Author, Cooperation:A. W. Lohse)

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  1. 1
    P. Ruibal ; L. Oestereich ; A. Ludtke ; B. Becker-Ziaja ; D. M. Wozniak ; R. Kerber ; M. Korva ; M. Cabeza-Cabrerizo ; J. A. Bore ; F. R. Koundouno ; S. Duraffour ; R. Weller ; A. Thorenz ; E. Cimini ; D. Viola ; C. Agrati ; J. Repits ; B. Afrough ; L. A. Cowley ; D. Ngabo ; J. Hinzmann ; M. Mertens ; I. Vitoriano ; C. H. Logue ; J. P. Boettcher ; E. Pallasch ; A. Sachse ; A. Bah ; K. Nitzsche ; E. Kuisma ; J. Michel ; T. Holm ; E. G. Zekeng ; I. Garcia-Dorival ; R. Wolfel ; K. Stoecker ; E. Fleischmann ; T. Strecker ; A. Di Caro ; T. Avsic-Zupanc ; A. Kurth ; S. Meschi ; S. Mely ; E. Newman ; A. Bocquin ; Z. Kis ; A. Kelterbaum ; P. Molkenthin ; F. Carletti ; J. Portmann ; S. Wolff ; C. Castilletti ; G. Schudt ; A. Fizet ; L. J. Ottowell ; E. Herker ; T. Jacobs ; B. Kretschmer ; E. Severi ; N. Ouedraogo ; M. Lago ; A. Negredo ; L. Franco ; P. Anda ; S. Schmiedel ; B. Kreuels ; D. Wichmann ; M. M. Addo ; A. W. Lohse ; H. De Clerck ; C. Nanclares ; S. Jonckheere ; M. Van Herp ; A. Sprecher ; G. Xiaojiang ; M. Carrington ; O. Miranda ; C. M. Castro ; M. Gabriel ; P. Drury ; P. Formenty ; B. Diallo ; L. Koivogui ; N. Magassouba ; M. W. Carroll ; S. Gunther ; C. Munoz-Fontela
    Nature Publishing Group (NPG)
    Published 2016
    Staff View
    Publication Date:
    2016-05-07
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    CTLA-4 Antigen/metabolism ; Ebolavirus/*immunology ; Female ; Flow Cytometry ; Guinea/epidemiology ; Hemorrhagic Fever, Ebola/*immunology/mortality/*physiopathology ; Humans ; Inflammation Mediators/immunology ; Longitudinal Studies ; Lymphocyte Activation ; Male ; Patient Discharge ; Programmed Cell Death 1 Receptor/metabolism ; Survivors ; T-Lymphocytes/*immunology/metabolism ; Viral Load
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2018-02-09
    Publisher:
    BMJ Publishing Group
    Print ISSN:
    0017-5749
    Electronic ISSN:
    1468-3288
    Topics:
    Medicine
    Published by:
    http://www.bmj.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    ISSN:
    1432-2307
    Keywords:
    Key words Immunopathology of bile ducts ; T lymphozyte subtyping ; Epithelial cells as immune targets
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract  Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are chronic autoimmune-mediated diseases of the biliary tree, resulting in a loss of bile ducts. There are morphological features that clearly distinguish them from each other: in PBC, there is overt destruction of the bile ducts with disruption of the basement membrane; in PSC there is abundant periductular fibrosis with shrinkage and subsequent loss of the bile ducts. In order to see if the disparate histopathology is paralleled by different immunohistology we looked at a panel of epitopes on bile duct epithelia especially to see if biliary epithelial cells may present as targets for cell mediated immune respone. In PBC bile duct epithelial cells mostly expressed CD58 (lymphocyte function-associated antigen 3), CD80 (B7 BB1), and CD95 (Fas). In PSC, however, these epitopes were only expressed in a few examples to a lower degree. The respective effector T lymphocytes were positive for CD2 and CD28. Subtyping of the lymphocytes in the liver tissue further showed a predominance of CD4 positive T cells over CD8 cells up to 2-to-1 in both diseases. Determination of lymphocytes by cytokines to Th1 or Th2 subtype showed a majority of Th1 lymphocytes in PBC and PSC. We conclude that in PBC bile duct epithelial cells may display features of target cells of a T cell-mediated immune reaction with the Th1 cells predominating. In PSC other mechanisms of bile duct loss may play a role, since in this disease the majority of cells lack essential epitopes that constitute targets of cell mediated immunity.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004280050077

    Articles: DFG German National Licenses